32 Tests
DuplicαRealTime Gilbert’s Syndrome Genotyping Kit (UGT1A1)
DuplicαRealTime Gilbert’s syndrome Genotyping Kit is an in vitro diagnostic test for the detection, by Real-Time PCR, of the nucleotide substitution 6TA/7TA of the UGT1A1 gene in human genomic DNA.
Overview
Gilbert’s syndrome is caused by decreased hepatic levels of the enzyme glucuronosyltransferase. As this enzyme is responsible for the glucuronidation (conjugation) of bilirubine in the liver, reduced activity of the glucuronosyltransferase leads to the accumulation of unconjugated bilirubin in the circulation.
It is not a rare disease: 3-10% of the population presents this condition.
Targets:
- Nucleotide substitution 6TA/7TA of the UGT1A1 gene
- Internal Control (IC)
Diagnostic samples:
- Peripheral whole blood samples collected in EDTA
DNA Extraction:
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Compatible with the most common DNA Extraction and Purification Systems
Real-Time PCR instruments:
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Compatible with the most common Real-Time PCR Systems